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T4314 |
EPZ020411
|
EPZ020411 2HCl |
Histone Methyltransferase
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EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM). |
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T40350 |
HPK1-IN-4
|
HPK1-IN-4 |
MAPK
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HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound. |
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T63788 |
PCLX-001
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Others
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PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively. This compound demonstra... |
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T22180 |
3F8
|
3F 8,3F-8 |
GSK-3
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3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in the study of neurological disorders and cancer. |
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T9314 |
CC214-1
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mTOR
,
Autophagy
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CC214-1 is an mTOR inhibitor with potential anticancer activity, inhibits protein translation, and induces autophagy. CC214-1 is an in vitro tool compound for exploring the biology of mTOR kinases and can be used to stud... |
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T64355 |
TDI-10229
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cAMP
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TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50= 195 nM). TDI-10229 exhibits mo... |
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T9361 |
5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
|
5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
Others
|
|
5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione (5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) is a synthetic compound. It has been used as a catalyst and as a tool in enzyme kinetic studies; it has al... |
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T61868 |
Antitumor agent-66
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|
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Antitumor agent-66 (Compound 4) is a derivative of (-)-cleistenolide, showcasing potential as a research tool for cancer diseases [1]. |
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T38938 |
Antibacterial agent 37
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Antibacterial agent 37 is an effective antimicrobial compound. It holds potential as a valuable tool for researching bacterial infections. |
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T30216 |
AV-105
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AV105,AV 105 |
|
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Av-105 is the precursor of florbetapir (18F). It is a radiopharmaceutical compound scanned by pet, which can be used as a diagnostic tool for Alzheimer's disease. |
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T61423 |
Transthyretin-IN-1
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|
|
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Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1]. |
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T38955 |
β-Lactamase-IN-4
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|
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β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections. |
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T69922 |
EPZ020411 HCl
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|
|
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EPZ020411 is a potent and selective PRMT6 inhibitor tool compound. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies. EPZ020411 suppresses RCC1 argin... |
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T39729 |
HIV Protease Substrate 1
|
|
|
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HIV Protease Substrate 1 is a fluorogenic compound that offers insights into the enzymatic activity of HIV protease, making it a valuable tool for studying this aspect. |
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T18373 |
N-(Amino-PEG4)-N-Biotin-PEG4-acid
|
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Others
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N-(Amino-PEG4)-N-Biotin-PEG4-acid is a PEG-based PROTAC linker that incorporates biotin for labeling purposes. This compound serves as a versatile tool in the synthesis of PROTACs[1]. |
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T39270 |
2-NP-AMOZ
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|
|
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2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ, which is a metabolite of the antibiotic Furaltadone. This chemical compound specifically serves as a reliable tool for protein bound AMOZ detection. |
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T61592 |
Thalidomide-piperazine hydrochloride
|
|
|
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Thalidomide-piperazine hydrochloride is a chemical compound with potential applications in the research of leprosy and multiple myeloma. It serves as a valuable tool in developmental biology, facilitating significant dis... |
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T61341 |
A-908292
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|
|
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A-908292 is a highly potent and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), displaying an impressive IC50 of 38 nM. This compound serves as a valuable tool in the investigation of fatty acid metabolism [1]. |
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T40452 |
N-Acetylpsychosine
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N-Acetylpsychosine,C2 Galactosylceramide (d18:1/2:0) |
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N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties. This compound, N-Acetylpsychosine, holds potential as a valuable tool for studying the mechanisms of apop... |
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T39629 |
BRD4 ligand-Linker Conjugate 1
|
BRD4 ligand-Linker Conjugate 1 |
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BRD4 Ligand-Linker Conjugate 1 is a compound consisting of a ligand and a linker, specifically designed to bind to the target protein BRD4. This conjugate serves as a valuable tool for synthesizing PROTACs, molecules uti... |
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T17884 |
CIAP1 Ligand-Linker Conjugates 11 Hydrochloride
|
E3 ligase Ligand-Linker Conjugates 33 Hydrochloride |
Others
|
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cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. It is primarily utilized in the development of SNIPERs,... |
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T61502 |
Antifungal agent 32
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Antifungal agent 32 (compound 1a) is a highly effective antifungal compound. It displays strong inhibitory activity against Candida albicans filamentation and biofilm formation, as well as inhibiting the morphological sw... |
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T61565 |
KDM5B-IN-3
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KDM5B-IN-3 (Compound 5) is an inhibitor of histone lysine-specific demethylase 5B (KDM5B) or JARID1B. It effectively inhibits the activity of KDM5B with an IC50 value of 9.32 μM. Consequently, KDM5B-IN-3 serves as a valu... |
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T79131 |
KAT modulator-1
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Histone Acetyltransferase
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KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1]. |
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T74339 |
DNA crosslinker 3 dihydrochloride
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DNA Crosslinker 3 (dihydrochloride) (Compound 1) is a potent minor groove binder, exhibiting a DNA binding affinity (ΔTm) of 1.4°C, and serves as a valuable tool in anticancer research [1]. |
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T38980 |
Mg(II) protoporphyrin IX
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Mg(II) protoporphyrin IX is a crucial compound in the synthesis of chlorophyll in Chlorella. It also serves as a negative regulator of nuclear photosynthetic gene expression. Additionally, Mg(II) protoporphyrin IX is emp... |
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T61073 |
KH-259
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KH-259 (compound 1) is a highly potent, selective, and CNS-penetrant HDAC6 inhibitor, demonstrating an IC50 of 0.26 μM. It exerts its antidepressant effects in mice by inhibiting HDAC6 within the brain. Therefore, KH-259... |
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T18552 |
Pomalidomide-amido-C1-Br
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Others
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Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTA... |
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T39791 |
Mal-amide-PEG2-oxyamine-Boc
|
Mal-amide-PEG2-oxyamine-Boc |
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Mal-amide-PEG2-oxyamineBoc is a polyethylene glycol (PEG)-based linker molecule that possesses a Boc-protected oxyamine functionality. This compound serves as a valuable tool in the efficient synthesis of PROTACs (proteo... |
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T74959 |
Antifungal agent 41
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|
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Antifungal Agent 41 (compound B01), an effective inhibitor of Candida albicans both in vitro and in vivo, is a potential research tool for invasive fungal infections [1]. |
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T61796 |
MtTMPK-IN-1
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MtTMPK-IN-1 (compound 3) is a highly effective inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), exhibiting an IC50 value of 2.5 μM. It displays moderate to weak activity against Mtb H37Rv while demon... |
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T39074 |
(Rac)-Zevaquenabant
|
(Rac)-MRI-1867,(Rac)-Zevaquenabant |
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(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of the cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity (Ki) of 5.7 nM sp... |
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T39578 |
TPh A
|
Triphenyl Compound A |
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Triphenyl Compound A (TPh A) is an effective inhibitor of nuclear protein pirin, showing specific binding to pirin with a Ki value of 0.6 uM. Its mechanism of action involves disturbing the formation of the bcl3–pirin co... |
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T61777 |
Anticancer agent 42
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|
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Anticancer agent 42 (compound 10d) is an orally active, potent anticancer agent with demonstrated efficacy against MDA-MB-231 cells, exhibiting an IC50 of 0.07 μM. It exerts its anticancer activity through the activation... |
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T61785 |
BChE-IN-6
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|
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BChE-IN-6 (compound 12) is a highly effective inhibitor of BChE, showcasing a Ki value of 0.182 μM. Notably, BChE-IN-6 exhibits significant chelating abilities towards Zn 2+. Due to these characteristics, BChE-IN-6 serve... |
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T61543 |
CLK1/4-IN-1
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CLK1/4-IN-1 (compound 31) is a highly potent and selective inhibitor of Clk1 and Clk4, with IC50 values of 9.7 nM and 6.6 nM, respectively. It effectively inhibits the growth of T24 cancer cells, with a GI50 value of 1.1... |
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T61732 |
EGFR/HER2-IN-6
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EGFR/HER2-IN-6 (compound 43) is a dual EGFR/HER2 and DHFR inhibitor with potent activity against EGFR kinase, HER2 kinase, and DHFR, characterized by IC50 values of 0.122 μM, 0.078 μM, and 0.585 μM, respectively. This co... |
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T61579 |
BuChE-IN-5
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BuChE-IN-5 (compound 25b) is a highly potent BuChE inhibitor, displaying an IC50 value of 1.94 μM. It effectively inhibits aggregation of Aβ and tau protein in Escherichia coli. Furthermore, BuChE-IN-5 exhibits considera... |
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T61573 |
MtTMPK-IN-5
|
|
|
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MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 value of 34 μM. Additionally, MtTMPK-IN-5 exhib... |
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T40131 |
SGC-CK2-1
|
SGC-CK2-1 |
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SGC-CK2-1 is an ATP-competitive chemical compound that acts as a highly potent and cell-active CK2 inhibitor. It demonstrates excellent selectivity towards both isoforms of human CK2, with IC50 values of 36 nM for CK2α a... |
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T39772 |
BRK inhibitor P21d hydrochloride
|
BRK inhibitor P21d hydrochloride |
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BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BR... |
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T82801 |
C12 NBD Galactosylceramide
|
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C12 NBD Galactosylceramide, a fluorescent dye-labeled variant of galactosylceramide, possesses a C12 nitrobenzoxadiazole (C12 NBD) moiety that enables fluorescence. This compound serves as a tool in imaging research [1]. |
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T24692 |
QAQ dichloride
|
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|
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QAQ dichloride is a photoswitchable compound that blocks voltage-gated Na v and K v channels. Its channel-blocking activity is observed in the trans form of the azobenzene photoswitch, while the cis form does not exhibit... |
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T14593 |
Biotin-PEG3-Mal
|
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Others
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Biotin-PEG3-Mal is a biotinylated polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs). By introducing the biotin moiety, it enables specific recognition and ... |
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T61739 |
Dyrk1A-IN-5
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Dyrk1A-IN-5 (compound 5j) is a highly potent and selective inhibitor of DYRK1A, exhibiting an IC50 of 6 nM. It dose-dependently diminishes the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Moreover, Dyrk1A-... |
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T39109 |
ML338
|
ML338 |
|
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ML338 is a selective small molecule inhibitor probe specifically targeting non-replicating Mycobacterium tuberculosis bacilli. It exhibits potent activity against non-replicating M. tuberculosis, with IC90 and IC99 value... |
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T79315 |
PROTAC TG2 degrader-2
|
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PROTACs
|
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PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM. It inhibits cell migration and reduces TG2 levels in ovaria... |
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T74271 |
TRIM24/BRPF1-IN-2
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TRIM24/BRPF1-IN-2 (compound 20l) is an effective dual inhibitor of TRIM24/BRPF1, demonstrating IC50 values of 0.98 μM for TRIM24 and 1.16 μM for BRPF1, respectively. It exhibits strong binding affinity to the bromodomain... |
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T77967 |
MS159
|
|
PROTACs
|
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MS159 is a potent PROTAC degrader targeting the nuclear receptor binding SET structural domain protein 2 (NSD2), which inhibits tumor cell growth. This compound serves as a valuable chemical tool for investigating NSD2's... |
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T81233 |
S-(p-Nitrobenzyl)glutathione
|
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S-(p-Nitrobenzyl)glutathione acts as a competitive inhibitor of glutathionase. Rat kidney microsomes convert this compound into associated cysteine derivatives. It serves as a research tool in investigating the catabolis... |
